American scientists from Worcester Polytechnic Institute have developed a unique technology to eliminate the badly damaged muscle tissue. The technology is based procedure for implanting microthreads, coated with human muscle cells, reports Informnauka.
Have proven the effectiveness of brand viagra online experiments with rodents, which had great wound. Filaments help cells to grow properly, delaying wound. According to the developer of technology, George Pins, cells migrate along the scaffold, which perform the role string. Implants are quickly incorporated into existing muscle and significantly reduce scar tissue formation.
Presented filaments are composed of fibrin - protein polymer used by the body to heal wounds. To obtain filaments scientists had to master the technology of simultaneous extrusion of fibrinogen (the building blocks of fibrin) and thrombin (an enzyme that catalyzes the reaction of synthesis of soluble protein fibrinogen to polymer) of two small tubes. The diameter of fibers was obtained from 500 to 100 microns, in 5 -10 times the size of the cell. Next, the scientists "seeded" the thread of human muscle cells derived from post-operative waste.
In rodents, specifically was removed about 30% of the tibialis anterior muscle for subsequent implantation there microthreads. Bottom line: the wound quickly tightened with a significant reduction of scarring. As specialists say, the thread replacing the natural signaling generic viagra system that controls the healing process. They are also attracted to the enzyme breaks the fibrin fibrinogen into individual proteins that make the surrounding cells to migrate and grow new tissue.
According to estimates, the cells were embedded in tissue injury in a few days. A week later, the thread begin to decompose, giving way to the muscle fibers. After ten weeks, the wound completely filled with human cells that look like mature muscle fibers. Now researchers are going to test the effectiveness of the grown fibers.
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